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COMPOSITION FOR THE TREATMENT OF GLIOMA AND RELATED EPILEPSY
[Category : - HEALTH]
[Viewed 536 times]
A new formulation has been developed to inhibit cancer cell proliferation, which blocks the increase in cell volume necessary for their replication, as well as a patented combination of FDA-approved compounds for the treatment of glioma and glioma-induced epilepsy. The composition has an almost negligible effect on the electrical activity of healthy neurons. In addition, infliximab reduces epileptic discharges induced in neurons by exosomes derived from glioma patients (of all grades). The formulation includes R-Ketorolac, Bumetadine, at least one Cl channel and Infliximab (intended for use in the treatment of glioma-associated epilepsy). The possible combinations of inhibitors (ion channels, membrane and cytoskeletal proteins) for specific cancer types are endless, and our team has decades of experience in modulating these targets. We are currently validating new drug combinations for breast and colorectal cancers.
POSSIBLE APPLICATIONS:
Can be further developed into new lipophilic prodrugs formulations for blood-brain barrier penetration; Bumetanide can be administered in the form of lipophilic prodrugs for CNS targeting; Effectiveness in treating different neurological disorders, ie schizophrenia, autism, temporal lobe epilepsy.
ADVANTAGES: The formulation has:
(a) An inhibitory effect on the infiltration (invasiveness) of brain tumour cells while not blocking the physiological neuronal signalling; (b) A potential antiepileptic effect on neuronal circuits, in particular when affected by tumour-released exosomes.
Patent publications:
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