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GIPs/FILIP1L (filamin A-interacting protein 1-like) proteins

[Category : - HEALTH]
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The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical compositions thereof. The present invention also provides isolated GIP90/130 nucleic acid sequences, expression vectors comprising the nucleic acid sequences, and host cells transfected with the expression vectors (from abstract published in the USPTO website).

FILIP1L proteins have been recognized as putative targets in cancer (Kwon M, Libutti SK.. 2014. Expert Opin Ther Targets. 18:1435-47.). GIPs are 90-kDa and 130-kDa FILIP1L isoforms that bind to Goodpasture antigen binding protein (GPBP) also known as Ceramide transfer protein or CERT. FILIP1L-130 kDa and GPBP are involved in myofibril formation (Revert-Ros et al. 2011. J Biol Chem. 286:35030-43.)

Issued patents corresponding to this invention include:

US Patents 7147855, US Patent 7601349, Australia Patent 2002365637, Japan Patent 4201712.





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