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[Category : - HEALTH]
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The present invention refers to a mutated amino acid sequence, a mutated receptor-binding domain and a mutated Spike protein of SARS-CoV-2 with reduced adherence to Angiotensin Converting Enzyme-2 (ACE-2), antibodies that specifically binds to them, pharmaceutical and/or veterinary compositions comprising them, nucleic acids that encode them and therapeutic and prophylactic uses. In particular, the present invention refers to their uses in the prophylaxis and/or treatment of a SARS-CoV-2 infection and COVID disease.

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